While many of the first generation hemostatic agents had problems and are no longer commercially available, third generation dressings have few issues and made with chitosan or kaolin. Dressings made with chitosan—Celox Gauze, ChitoGauze, and Chito-SAM—react with blood to form a localized clot independent of the normal clotting cascade. Dressings made with kaolin—Combat Gauze—activate the intrinsic coagulation pathway. Unlike kaolin, that remains in the body, chitosan is naturally broken down by bodily enzymes and cleared. Since Chito-SAM gauze is made from 100% chitosan (rather than chitosan impregnated gauze) and can be left in the wound longer than other hemostatic dressings, it is more suitable for use in remote settings when evacuation is delayed.